Lithium alters calcium homeostasis Inhibition of Phosphoglucomutase Activity by Lithium Alters Cellular Calcium Homeostasis and Signaling in Saccharomyces cerevisiae
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چکیده
Department of Laboratory Medicine, Faculty of Medicine, Pécs University, Ifjúság u. 13., 7624 Pécs, Hungary Department of Immunology and Biotechnology, Faculty of Medicine, Pécs University, Szigeti u. 12., 7624 Pécs, Hungary Department of Biochemistry, Faculty of Medicine, Pécs University, Szigeti u. 12., 7624 Pécs, Hungary Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-2170, USA
منابع مشابه
Inhibition of phosphoglucomutase activity by lithium alters cellular calcium homeostasis and signaling in Saccharomyces cerevisiae.
Phosphoglucomutase is a key enzyme of glucose metabolism that interconverts glucose-1-phosphate and glucose-6-phosphate. Loss of the major isoform of phosphoglucomutase in Saccharomyces cerevisiae results in a significant increase in the cellular glucose-1-phosphate-to-glucose-6-phosphate ratio when cells are grown in medium containing galactose as carbon source. This imbalance in glucose metab...
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Loss of the major isoform of phosphoglucomutase (PGM) causes an accumulation of glucose 1-phosphate when yeast cells are grown with galactose as the carbon and energy source. Remarkably, the pgm2 strain also exhibits a severe imbalance in intracellular Ca homeostasis when grown under these conditions. In the present study, we examined how the pgm2 mutation alters yeast Ca homeostasis in greater...
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Glutaredoxin 6 (Grx6) of Saccharomyces cerevisiae is an integral thiol oxidoreductase protein of the endoplasmic reticulum/Golgi vesicles. Its absence alters the redox equilibrium of the reticulum lumen toward a more oxidized state, thus compensating the defects in protein folding/secretion and cell growth caused by low levels of the oxidase Ero1. In addition, null mutants in GRX6 display a mor...
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A gene, TIF2, was identified as corresponding to the translation initiation factor eIF4A and when overexpressed it confers lithium tolerance in galactose medium to Saccharomyces cerevisiae. Incubation of yeast with 6 mm LiCl in galactose medium leads to inhibition of [(35)S]methionine incorporation. By polysome analysis we show that translation is inhibited by lithium at the initiation step, ac...
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There is increasing evidence of adverse health effects due to elevated lithium exposure through drinking water but the impact on calcium homeostasis is unknown. This study aimed at elucidating if lithium exposure through drinking water during pregnancy may impair the maternal calcium homeostasis. In a population-based mother-child cohort in the Argentinean Andes (n=178), with elevated lithium c...
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تاریخ انتشار 2005